1. Debilitating stroke.

2. Bone marrow aplasia and other chronic types of cytopenia

3. Chronic arterial disease with ischemic events  

4. Complicated schistosomiasis  

5. Chronic heart failure, chronic heart valve disease, serious heart arrhythmia, chronic congenital heart disease

6. Chronic liver disease and cirrhosis

7. Severe primary immunodeficiency disorder requiring long-term treatment, human immunodeficiency virus (HIV)

8. Type 1 diabetes and type 2 diabetes

9. Severe neurological and muscular disorders (including myopathy), severe epilepsy

10. Haemoglobinopathy, chronic constitutional/severe acquired haemolysis

11. Haemophilia and severe constitutional haemostatic disorders

13. Coronary artery disease

14. Acute/chronic respiratory failure

15. Leprosy

16. Parkinson’s disease

17. Inherited metabolic disorders requiring long-term specialised treatment

18. Cystic fibrosis

19. Acute/chronic nephropathy and primary nephrotic syndrome

20. Paraplegia

21. Periarteritis nodosa, acute disseminated lupus erythematosus, progressive systemic sclerosis

22. Severe progressive rheumatoid arthritis

23. Long-term psychiatric disorders

24. Ulcerative colitis and progressive Crohn’s disease

25. Multiple sclerosis

26. Progressive structural scoliosis (where the curve is 25 degrees of more) through to spinal maturity

27. Severe ankylosing spondylitis

28. Organ transplant disorders

29. Active tuberculosis

30. Malignant tumour, lymphoma or haematopoietic cancer.